Euk-134 Ethylbisiminomethylguaiacol Manganese Chloride 81065-76-1 Antioxidant

EUK-134

INCI Name: Ethylbisiminomethylguaiacol Manganese Chloride

CAS Number: 81065-76-1

Synonym: 2,2′-[1,2-Ethanediylbis(nitrilomethylidyne)]bis[6-methoxy-phenol manganese complex

Appearance: Dark brown to reddish powder

EUK-134 has dual antioxidant function i.e. superoxide dismutase and catalase mimetic activities.Its therapeutic use and studies conducted are based on its property to reduce reactive oxygen species (ROS) induced cellular injury in the body. It is a  low-molecular-weight synthetic complex that has better potency, stability, and bioavailability than endogenous antioxidant enzymes.

EUK-134 can act as a scavenger for oxidative species such as hydrogen peroxide, peroxynitrite and superoxide. This compound is a salen-manganese complex that has been modified to increase its catalase activity while retaining SOD activity.

EUK-134 has the unique and amazing capacity of regenerating itself during its free radical scavenging action. Thereby, EUK-134, represents a complete nature mimetic antioxidant system that can be used as an active cosmetic ingredient to limit premature aging, reduce photo-aging, protect the skin and its DNA from sun damage and decrease redness.

The two important antioxidant components in the human body are: superoxide dismutase (SOD) and catalase (CAT). These two components work closely together to convert the ROS  produced in the metabolic process into water and oxygen to maintain the body’s normal metabolism.

The synthetic SOD/ CAT mimetic EUK-134 might be able to compensate for seasonal deficiencies in antioxidant defense capacity at the skin surface, protecting the skin against oxidative damage.

NOTE: Please avoid EUK-134 if you have known hypersensitivity to manganese. Always do a patch test on the upper forearm with the product to test for possible allergic reaction.